Novel b7-4 molecules and uses therefor

Details Novel b7-4 molecules and uses therefor Novel b7-4 molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2383424

The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées, dites molécules d'acide nucléique B7-4, qui codent pour des polypeptides B7-4. Elle concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression de recombinaison contenant des molécules d'acide nucléique B7-4, des cellules hôtes dans lesquelles on a introduit lesdits vecteurs, et des animaux transgéniques non humains dans lesquels on a introduit ou perturbé un gène B7-4. Elle concerne en outre des protéines B7-4, des protéines de fusion, des peptides antigènes et des anticorps B7-4. Elle traite également de procédés de diagnostic, de criblage et de traitement faisant appel à des compositions selon l'invention.

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