C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/42 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) C07D 311/68 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2175458
The present invention relates to novel benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheumatoid arthritis, multiple sclerosis, diabetes mellitus, atherosclerosis, septic shock and pulmonary fibrosis.
La présente invention se rapporte à de nouveaux dérivés de benzènesulfonylimine ainsi qu'à l'utilisation de ceux-ci en tant qu'inhibiteurs de l'action de l'Interleukine-1 (IL-1). De tels inhibiteurs sont utiles dans le traitement de divers états maladifs tels ceux décrits ici, notamment l'arthrite rhumatoïde, la sclérose en plaques, le diabète sucré, l'athérosclérose, le choc septique et la fibrose pulmonaire.
Dalton Christopher R.
Harrison Boyd L.
Ku George
Meikrantz Scott B.
Stemerick David M.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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