Novel benzimidazole derivatives

Details Novel benzimidazole derivatives Novel benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/395 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2198266

The present invention provides novel benzimidazole derivatives or salts thereof represented by general formula (1), wherein R t is a hydrogen atom or a halogen atom R2 is a phenyl-lower alkyl group; R3 is a heterocyclic group selected from the group consisting of an indolyl group, indolinyl group, 1H-indazolyl group, 2(1H)-quinolinonyl group, 3,4dihydro-2(1H)-quinolinonyl group and 1,4-benzoxazinyl group; A is a lower alkylene group; n is 0 or 1. The benzimidazole derivatives or salts of the present invention are effective agents for treating various arteriosclerotic diseases.

Nouveaux dérivés de benzimidazole ou sels desdits dérivés, de formule générale (1) dans laquelle R<1> est un atome d'hydrogène ou un atome d'halogène, R<2> est un groupe phényle-alkyle inférieur, R<3> est un groupe hétérocyclique choisi dans le groupe constitué d'un groupe indolyle, d'un groupe indolinyle, d'un groupe 1H-indazolyle, d'un groupe 2(1H)-quinolinonyle, d'un groupe 3,4-dihydro-2(1H)-quinolinonyle et d'un groupe 1,4-benzoxazinyle, A est un groupe alkylène inférieur, n est 0 ou 1. Lesdits dérivés de benzimidazole ou sels de la présente invention sont des agents efficaces pour traiter diverses maladies artérioscléreuses.

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