Novel benzimidazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/415 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2196792

The invention provides compounds having structure (I), wherein each of R1, R2, R3 and R9 is independently H; straight chain, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; cycloalkyl, cycloalkenyl; acyl; phenyl; substituted phenyl or heteroaryl; wherein each R4, R5 and R6 is independently H; F; Cl; Br; I; straight chain, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; cycloalkyl; cycloalkenyl; phenyl; unsubstituted phenyl; heteroaryl; etc. and wherein each R8 is independently H; straight, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; phenyl or substituted phenyl. These compounds are selective for cloned human alpha 2 receptors and are useful as analgesic, sedative or anaesthetic agents.

Cette invention se rapporte à des composés ayant la structure (I) dans laquelle chaque R¿1?, R¿2?, R¿3? et R¿9? représente, indépendamment H; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; cycloalkyle; cycloalcényle; acyle; phényle; hétéroaryle ou phényle substitué; chaque R¿4?, R¿5? et R¿6? représente, indépendamment, H, F, Cl, Br, I; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; cycloalkyle; cycloalcényle; phényle; phényle non substitué; hétéroaryle; etc. et chaque R¿8? représente indépendamment H; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; phényle ou phényle substitué. Ces composés sont sélectifs pour les récepteurs alpha 2 humains clonés et sont utilisés comme agents analgésiques, sédatifs ou anesthésiques.

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