Novel benzothiazole derivatives

Details Novel benzothiazole derivatives Novel benzothiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/64 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2172879

The object of the present invention is to provide novel benzothiazole derivatives and pharmaceutically acceptable salts thereof, which have a lipid lowering activity and are useful as a medicine. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (I): Image (I) wherein R1 is halogen, alkyl, trifluoromethyl, acetamido or -OX1; X1 is hydrogen, alkyl or acyl; R2 is hydrogen, halogen, alkyl, hydroxyalkyl, trifluoro- methyl, nitro, amino which may be substituted with alkyl or acyl, carboxy which may be esterified with alkyl, or -OX2; X2 is hydrogen, alkyl, acyl, carboxyalkyl which may be esterified with alkyl; or n is an integer from 1 to 3 which means a number of substituent R2; and plural R2 may be the same or different when n is 2 or 3; with the proviso that R1 is a group other than chloride when R2 is hydrogen. The benzothiazole derivatives of the present invention have excellent pharmacological activities which significantly decrease cholesterol, triglyceride and low-density lipoprotein in blood. Therefore, they are novel compounds which are very useful as medicines such as a remedy for hyperlipemia.

Affiliated with

Also associated with

Rating

Novel benzothiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel benzothiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel benzothiazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1918555