C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/33 (2006.01) A61P 43/00 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2449771
The invention concerns compounds of general formula (I), wherein, in particular: W represents H, SO¿2?R¿5?, CO(CH¿2?)¿n?R¿5?, (CH¿2?)¿n?R¿6?, CS(CH¿2?)¿n?R¿5?; X represents S or NH; Y represents (CH¿2?)¿p?, CO, (CH¿2?)¿p?CO, CH=CH-CO; Z represents a heterocycle, imidazole, benzimidazole, isoxazole, tetrazole, oxadiazole, thiadazole, pyridine, quinazoline, quinoxaline, quinoline, thiophene; R¿1? represents COOR¿6?, CONR¿6?R¿7?, CO-NH-CH(R¿6?)-COOR¿7?, CH¿2?NR¿6?R¿7?, CH¿2?OR¿6?, (CH¿2?)¿p?R¿6?, CH=CHR¿6?; R¿2? represents in particular hydrogen, C¿1?-C¿10? alkyl, a substituted or unsubstituted phenyl; R¿3? and R¿4? represent hydrogen, C¿1?-C¿6? alkyl; R¿5? represents a substituted or unsubstituted phenyl or naphthyl; R¿6? and R¿7?, identical or different, represent hydrogen, C¿1?-C¿15? alkyl, a heterocycle, an aryl; n represents 0 to 10; p represents 1 to 6.
L'invention se rapporte à des composés répondant à la formule générale (I): dans laquelle, en particulier, W représente H, SO2R5, CO(CH2)nR5, (ch2)nR6, CS(CH2)nR5; X représente S ou NH; Y représente (CH2)p, CO, (CH2)PCO, CH=CH-CO; Z représente un hétérocycle, imidazole, benzimidazole, isoxazole, tétrazole, oxadiazole, thiadiazole, pyridine, quinazoline, quinoxaline, quinoline, thiophène; R1 représente COOR6, CONR6R7, CO-NH-CH(R6)-COOR7, CH2NR6R7, CH2OR6, (CH2)PR6, CH=CHR6; R2 représente notamment Hydrogène, C1-C10 alkyle un phényle non substitué ou substitué R3 et R4 représente Hydrogène, C1-C6 alkyle; R5 représente un Phényle ou un naphtyle non substitué ou substitue; R6 et R7 identiques ou différents, représentent Hydrogène, C1-C15 alkyle, un hétérocycle, un aryle; n représente 0 à 10 p représente 1 à 6.
Etievant Chantal
Hill Bridget
Lamothe Marie
Perez Michel
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pierre Fabre Medicament
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