Novel benzothiophene analogs as antiviral agents

Details Novel benzothiophene analogs as antiviral agents Novel benzothiophene analogs as antiviral agents

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/435 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2168463

Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus are pro- vided. These antiviral agents have structural formula (I) wherein R and R1 are as defined herein, and may be in free base or acid addition salt form. Pharmaceuti- cal compositions are provided containing the antiviral agents, as are methods of treating herpes-infected in- dividuals.

Des analogues de benzothiophène sont utilisés pour traiter des infections virales herpétiques, notamment par le cytomégalovirus. Ces agents antiviraux ont la formule structurale (I) dans laquelle R et R<1> sont tels que définis dans la formule, et peuvent être sous forme de base libre ou de sel d'addition d'acide. On décrit des compositions pharmaceutiques contenant les agents antiviraux, ainsi que des procédés de traitement d'individus souffrant d'herpès.

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