Novel benzothiophene derivatives

Details Novel benzothiophene derivatives Novel benzothiophene derivatives

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/427 (2006.01) A61K 31/4436 (2006.01) A61P 5/28 (2006.01) A61P 5/32 (2006.01) A61P 35/00 (2006.01) C07D 409/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2409821

Novel benzothiophene derivatives of the general formula (I) or salts thereof; and inhibitors against steroid 17a hydroxylase and/or C17-20 lyase, or pharmaceutical compositions, containing the derivatives or the salts (I), wherein Ar is a substituted or unsubstituted aromatic heterocyclic group; and R is amino which may be mono- or di-substituted with one or more members selected from among hydroxyl, lower alkyl, lower alkyloxy, halogeno, carboxyl, lower alkyloxycarbonyl, carbamoyl, amino, lower alkyl, and lower acyl ; cyano; optionally substituted phenyl; optionally substituted phenoxy; optionally substituted phenyl-lower alkyl; optionally substituted phenyl- lower alkyloxy; or an optionally substituted aromatic heterocyclic group.

L'invention concerne de nouveaux dérivés de benzothiophène de formule générale (I) ou des sels de ces derniers, ainsi que des inhibiteurs agissant contre l'hydrolase stéroïde 17.alpha. et/ou la lyase C17-20, ou des compositions pharmaceutiques contenant ces dérivés ou ces sels. Dans la formule (I), Ar est un groupe hétérocyclique aromatique substitué ou non substitué ; R représente amino pouvant être mono- ou di-substitué avec un ou plusieurs éléments sélectionnés parmi hydroxyle, alkyle inférieur, alkyloxy inférieur, halogéno, carboxyle, alkyloxycarbonyle inférieur, carbamoyle, amino, alkyle inférieur et acyle inférieur, cyano, phényle éventuellement substitué, phénoxy éventuellement substitué, phényl-alkyle inférieur éventuellement substitué, phényl-alkyloxy inférieur éventuellement substitué, ou un groupe hétérocyclique aromatique éventuellement substitué.

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