Novel benzoxathiin derivative

Details Novel benzoxathiin derivative Novel benzoxathiin derivative

C - Chemistry, Metallurgy

07

D

C07D 327/06 (2006.01) A61K 31/4025 (2006.01) A61K 31/4365 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 19/06 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/32 (2006.01) A61P 25/36 (2006.01) A61P 43/

Patent

CA 2627139

Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent -CH-, a nitrogen atom or the like.]

La présente invention concerne un composé représenté par la formule (I) ci-dessous et un sel pharmaceutiquement acceptable de celui-ci. Ce composé est utile dans le traitement de l~obésité, du diabète et similaire. [Dans la formule (I), Ar représente un anneau benzène ou similaire ; X1 représente un atome d~azote, un atome de soufre ou similaire ; R1 représente un groupe aryle ou similaire ; X2 représente un groupe représenté par la formule suivante (II) : (où R4 et R5 représentent respectivement un groupe alkyle inférieur ou similaire et m représente un nombre entre 2 et 4) ou similaire ; parmi X et Y, l~un représente un atome d~oxygène et l~autre représente un groupe sulfanyle ou similaire ; X3-X6 représentent respectivement -CH- , un atome d~azote ou similaire.]

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