Novel benzoylecgonine compositions and methods for producing...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 451/06 (2006.01) C07D 451/02 (2006.01) C07D 451/12 (2006.01)

Patent

CA 2466062

This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaining the reaction mixture at a temperature between about 50~ and 100~ C; and (c) subsequently or simultaneously removing water from the reaction mixture. This invention also provides novel benzoylecgonine and methods for producing them.

L'invention concerne un procédé permettant de préparer une composition de benzoylecgonine. Les étapes de ce procédé consistent (a) à mettre en contact de la benzoylméthylecgonine et du propylène glycol en présence ou en l'absence d'eau, afin de former un mélange réactionnel, (b) à maintenir le mélange réactionnel à une température comprise entre 50· et 100 ·C, et (c) à éliminer subséquemment ou simultanément l'eau du mélange réactionnel. L'invention concerne également de nouvelles benzoylecgonines ainsi que des procédés permettant de produire celles-ci.

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