C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61P 25/28 (2006.01) C12N 9/48 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) G01N 33/537 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2368624
The invention concerns a novel .beta.-secretase, a method of partially purifying this novel .beta.-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel .beta.-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7Ø
La présente invention concerne une nouvelle .beta.-secrétase, un procédé de purification partielle de cette nouvelle .beta.-secrétase, et son utilisation dans des dosages pour le criblage de médicaments candidats potentiels destinés à traiter la maladie d'Alzheimer et autres troubles neurologiques. La nouvelle .beta.-secrétase présente un poids moléculaire estimé d'environ 32-39 kDa ou 22-26 kDa dans des extraits de membrane cellulaire HEK293 et des échantillons cérébraux humains, respectivement, comme il a été calculé à partir de l'analyse d'inactivation de rayonnement, cette nouvelle .beta.-secrétase présentant un pH optimum compris entre environ 6, 5 et 7, 0.
Cordell Barbara
Hyslop Paul Andrew
Johnstone Edward Marion
Little Sheila Parks
Liu Yu-Wang
Eli Lilly And Company
Scios Inc.
Sim & Mcburney
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