Novel betulinic acid derivatives, processes for preparing...

Details Novel betulinic acid derivatives, processes for preparing... Novel betulinic acid derivatives, processes for preparing...

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01) A61K 31/56 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2350786

The invention relates to novel betulinic acid derivatives of the structural formula shown hereinbelow having modifications at C2, C3, C17, C20 and/or C29 positions, (see formula I) Said derivatives being useful as inhibitors of tumor/cancer cells; process for preparation of the said derivatives; pharmaceutical compositions comprising said derivatives useful in the treatment of ovarian, colon, lung, laryngeal, prostrate cancer, leukemia, lymphoma and a method of treatment of ovarian, colon, lung, laryngeal and prostrate cancer in mammals using said derivatives or compositions.

La présente invention concerne des dérivés de l'acide bétulinique de formule structurale comportant des modifications aux positions C2, C3, C17, C20 et/ou C29. Lesdits dérivés sont utiles comme inhibiteurs de cellules tumorales/cancéreuses. L'invention concerne aussi de procédés de préparation de ces dérivés, des compositions pharmaceutiques contenant ces dérivés, utiles dans le traitement de cancers de l'ovaire, du colon, du poumon, laryngien, de la prostate, de leucémie, de lymphome ainsi qu'une méthode de traitement des cancers de l'ovaire, du colon, du poumon, laryngien et de la prostate chez les mammifères au moyen de ces dérivés ou compositions.

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