Novel bi- and tri-cyclic aza compounds and their uses

Details Novel bi- and tri-cyclic aza compounds and their uses Novel bi- and tri-cyclic aza compounds and their uses

C - Chemistry, Metallurgy

07

D

C07D 221/02 (2006.01) C07D 215/36 (2006.01) C07D 221/22 (2006.01) C07D 451/02 (2006.01) C07D 453/00 (2006.01) C07D 455/00 (2006.01) C07D 471/08 (2006.01) C07D 471/18 (2006.01) C07D 491/00 (2006.01) C07D 498/00 (2006.01) C07D 513/00 (2006.01)

Patent

CA 2339122

The present invention provides tropane-derived monoamine neurotransmitter re- uptake inhibitors which predictably exhibit selectivity for either the serotonin or dopamine transporter, pharmaceutical compositions thereof and methods for their use. The serotonin-selective re-uptake inhibitors are particularly useful for treating neurological disorders associated with the serotonergic neural system of the brain, such as depression, with significantly reduced side-effects. The dopamine-selective re-uptake inhibitors are particularly useful for treating disorders associated with dopamine re-uptake and/or acetylcholine release.

La présente invention concerne des inhibiteurs de re-captage des neurotransmetteurs de monoamines dérivées du tropane montrant de façon prévisible une sélectivité pour les transporteurs soit de sérotonine, soit de dopamine, des compositions pharmaceutiques renfermant ces inhibiteurs, et leurs méthodes d'utilisation. Les inhibiteurs de re-captage à sélectivité pour la sérotonine conviennent tout particulièrement pour le traitement de troubles neurologiques en rapport avec le système neural sérotoninergétique du cerveau, tels que la dépression, avec des effets secondaires sensiblement atténués. Les inhibiteurs de re-captage à sélectivité pour la dopamine conviennent tout particulièrement pour le traitement de troubles en rapport avec le re-captage de la dopamine et/la libération d'acétylcholine.

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