C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 65/26 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/33 (2006.01) C07C 43/23 (2006.01) C07C 65/17 (2006.01) C07C 65/19 (2006.01) C07C 65/40 (2006.01) C07C 69/017 (2006.01) C07C 69/86 (2006.01) C07C 69/92 (2006.01) C07C 69/94 (2006.01) C07C 217/48 (2006.01) C07C 229/64 (2006.01) C07C 235/60 (2006.01) C07C 251/48 (2006.01) C07D 295/192 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2103044
Bi-aromatic compounds characterized in that they comply with general formula (I), where: R1 is -CH3,-CH2OH, -COR8, or -CH2OCOR9, R8 is H, OH, -OR10, -N(rr'), or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl aralkyl, etc, r and r' together forming a heterocycle, R9 is alkyl, alkenyl or a sugar residue, R2 and R3 are -OR11 or -OCOR11, R11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R3 also being H, R4 is H, OH, alkyl, alkoxy, F, CI, -CF3, R5 and R7 are H, OH, alkoxy, substituted alkyl or .alpha.-.alpha.'-disubstituted alkyl etc, R6 is H, OH, alkyl, alkoxy, cycloalkyl, etc, R5 and R7 cannot simultaneously be OH or alkoxy and R4, R5, R6 and R7 cannot simultaneously be H, R5 and R6 or R6 and R7 may form a ring of 5 or 6 links with the aromatic ring. X is selected from (i) -C(R13R14-C(R16R18-W- ,(ii)-CR14R16-W-C(R18R19)- (iii) -C(R13R14)-C(R15R16-C(R18R20)-, (iv) -CR17=CR21-C(R13R14)- where W is 0, -NR12 or S(O)n, n = 0, 1 or 2, R13, R15 and R20 are H, -OR11, -OCOR11,etc,R14, R16, R18 and R19 are H, aralkyl, alkyl, etc, when X is (i), R13 and R14 may form =N-OR11 or = N-OCOR11, when X is (iii) or (iv), R14, R16 and R18 are also - OR11 or -OCOR11, or R13, R14 or R15, R16 together may form =NOR11 or =N-OCOR11, R12 is H, alkyl, aralkyl, alkenyl, alkynyl or fluoroalkyl, R17 is H, hydroxyl, alkyl or alkoxy, R21 is H or alkyl and the salts of the compounds of formula (I). Composé bi-aromatiques, caractérisés par le fait qu'ils répondent à la formule générale (I) dans laquelle: R1 est -CH3, -CH2OH, -COR8, ou -CH2OCOR9, R8 est H, OH, -OR10, -N(rr'), ou alkyle, R10 est alkyle, alkényle, aryle ou aralkyle, r et r' étant H, alkyle, aryle, aralkyle, etc, r et r' ensemble froment un hétérocycle, R9 est alkyle, alkénile ou un reste de alkyl, alcoxy, F, Cl, -CF2, R5 et R7 sont H, OH, alcoxy, alkyle substitué ou alkyle .alpha.-.alpha.'-disubstitué, etc, R6 est H, OH, alkyle, alcoxy, cycloalkyle, etc, R5 et R7 ne pouvant simultanément être OH ou alcoxy et R4, R5, R6 et R7 ne pouvant être simultanément H, R5 et R6 ou R6 et R7 peuvent former avec le cycle aromatique un cycle à 5 ou 6 chaînons, X est choisi parmi: (i) -C(R13R14)-C(R16R18)-W-, (ii) -C(R14R16)-W-C(R18R19)-, (iii) -C(R13R14)- C(R15R16)-C(R18R20)-, (iv) etc, R14, R16, R18 et R19 sont H, aralkyle, alkyle, etc, lorsque X est (i), R13 et R14 peuvent former =N-OR11 ou =N-OCOR11, lorsque X est (iii) ou (iv), R14, R16 et R18 sont également -OR11 ou -OCOR11, ou R13, R14 ou R15, R16, pris ensemble peuvent former =NOR11 ou =N-OCOR11, R12 est H, alkyle, aralkyle, alkényle, alkynyle ou fluoroalkyle, R17 est H, hydroxyle, alkyle ou alcoxy, R21 est H ou alkyle, et les sels des composés de formula (I).
Centre International de Recherches Dermatologiques Galderma (cir
Robic
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