C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/34 (2006.01) A61P 31/10 (2006.01) C07D 307/79 (2006.01) C07D 307/83 (2006.01) C07D 307/85 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 9/40 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2355694
The present invention is directed to new bicyclic compounds of formula (I), and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3 are as defined in the claims. The compounds have N- myristoyltransferase inhibitory and antifungal activity.
L'invention porte sur de nouveaux composés bicyclique de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, Q?1¿ Q?2¿ et Q?3¿ sont tels que définis dans les revendications, et sur leurs sels pharmacocompatibles. Lesdits composés présentent une activité inhibitrice vis à vis de la N-myristoyltransférase et une activité antifongique.
Aoki Yuhko
Ebiike Hirosato
Fujii Toshihiko
Kawasaki Kenichi
Liu Pingli
Basilea Pharmaceutica Ag
Gowling Lafleur Henderson Llp
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