C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/06 (2006.01) C07H 19/04 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2283509
An oligo- or polynucleotide analogue having one or more structures of the general formula (see formula I) where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.
Analogues d'oligo- ou de polynucléotide comprenant chacun une ou deux structures représentées par la formule générale (I), dans laquelle B représente une base d'acide nucléique de pyrimidine ou de purine ou un analogue de celle-ci. Les analogues de l'invention peuvent produire des molécules antisens d'analogues d'oligonucléotide qui sont moins susceptibles de subir une hydrolyse enzymatique in vivo, présentent une capacité élevée de liaison à des chaînes sens et sont faciles à synthétiser.
Imanishi Takeshi
Obika Satoshi
Exiqon A/s
Imanishi Takeshi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Santaris Pharma A/s
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