Novel bifunctional chelating compounds containing hydroxamic...

C - Chemistry – Metallurgy – 07 – C

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C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 51/00 (2006.01) A61P 35/00 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2432027

New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presence of a linker moiety in the molecular structure of these chelators.

L'invention se rapporte à de nouveaux types de chélateurs bifonctionnels utilisant un acide hydroxamique. Ces chélateurs ont pour mission de chélater des ions métalliques dont les propriétés paramagnétiques ou radioactives peuvent être détectées. On peut effectuer une conjugaison avec des peptides ou une protéine grâce à la présence d'un fragment lieur dans la structure moléculaire de ces chélateurs.

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