C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/44 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 213/68 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2705922
The present invention relates to a bifunctional compound of formula I or its pharmaceutically acceptable salts or solvates A-L-B (I) wherein A is a histone deacetylase (HDAC) inhibitory moiety, L is a single bond or a linker group and B is a protein kinase inhibitory moiety. The bifunctional compound according to formula (I) is useful for the treatment of malignant and non-malignant neoplasia and diseases related to abnormal cell growth.
La présente invention concerne un composé bifonctionnel de la formule I ou ses sels ou solvates acceptables du point de vue pharmaceutique A-L-B, (I) A étant une fraction inhibitrice d'histones désacétylases (HDAC), L étant une simple liaison ou un groupe de liaison et B étant une fraction inhibitrice de protéines kinases. Le composé bifonctionnel selon la formule (I) s'utilise pour le traitement d'une néoplasie maligne et non maligne et de maladies associées à une croissance cellulaire anormale.
Baer Thomas
Beckers Thomas
Ciossek Thomas
Mahboobi Siavosh
Maier Thomas
4sc Ag
Marks & Clerk
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