Novel bioactive substance

Details Novel bioactive substance Novel bioactive substance

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61K 31/4025 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/455 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/74 (2006.01) A61P 7/00 (2006.01) A61P 19/02 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 43/00 (2006.01) C07D 405/14 (2006.01) C07D 407/06 (2006.01) C07D 407/14 (2006.01) C07D 493/04 (2006.01) C07D 493/08 (2006.01) C07D 493/10 (2006.01) C12P 17/02

Patent

CA 2436667

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it. (see above formula)

L'invention concerne de nouvelles substances physiologiquement actives possédant un effet antitumoral, un procédé pour produire ces substances et l'utilisation de ces dernières à des fins médicales. Elle concerne en particulier des composés macrolides cycliques à 12 chaînons représentés par la formule générale (I), obtenus par culture de <i>Streptomyces sp.</i> Mer-11107 ou ses variantes, des sels pharmacologiquement acceptables ou des hydrates desdits composés, ainsi qu'un procédé pour leur production.

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