C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 421/04 (2006.01)
Patent
CA 2547186
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosome brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosome brucei rhodesiense infection.
Boykin David W.
Brun Reto
Ismail Mohamed A.
Stephens Chad E.
Tidwell Richard R.
Brun Reto
Georgia State University Research Foundation Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of North Carolina At Chapel Hill
Werbovetz Karl
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