Novel biomaterials, their preparation and use

Details Novel biomaterials, their preparation and use Novel biomaterials, their preparation and use

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/70 (2006.01) A61K 47/18 (2006.01) A61K 47/40 (2006.01) A61L 27/20 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2484100

The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: contacting the anionic polymeric component and an cylcodextrin component in an aqueous medium, and adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cycxlodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

L'invention concerne des matières nouvelles, en particulier des biomatières, sous forme de précipité, comprenant au moins un composant polymère anionique, soluble dans l'eau et un composant de type ammonium amphiphile, dont le précipité est obtenu par un procédé comprenant les étapes suivantes : mise en contact du composant polymère anionique et d'un composant de cyclodextrine dans un milieu aqueux, et ajout du composant de type ammonium amphiphile au mélange obtenu dans l'étape 1. Lesdits composants sont présents en quantité efficace pour former ledit précipité. L'invention concerne de préférence des précipités correspondants comprenant de plus ledit composant de cyclodextrine. Les deux types de précipités peuvent comprendre éventuellement un ou plusieurs composants supplémentaires. Les précipités sont utiles en particulier en tant que formulations de dépôt à libération contrôlée permettant une distribution de longue durée desdits composants supplémentaires. Lesdits composants supplémentaires incorporés aux précipités peuvent être des composés pharmaceutiques, des pesticides, des produits agrochimiques, des colorants, des produits diagnostiques, des enzymes, des produits alimentaires ou analogues.

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