Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers

Details Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2645350

The present invention provides a novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula (VII); wherein, n is 3 to 10. novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula VII exhibits biding affinity with calf thymus (CT) DNA at a molar ratio of 1:5 in aqueous sodium phosphate buffer at pH of about 7.00. The present invention further provides a process for the preparation of novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula (VII).

La présente invention concerne une nouvelle bis-2-difluoropyrrolo[2,1-c][1,4]benzodiazépine de formule (VII); où n est compris entre 3 et 10 inclus. La nouvelle bis 2-difluoropyrrolo[2,1-c][1,4]benzodiazépine de formule VII présente des affinités de liaison avec l'ADN de thymus de veau (TV) dans un rapport molaire de 1 : 5 dans un tampon phosphate de sodium aqueux à un pH d'environ 7,00. La présente invention concerne en outre un procédé de synthèse de la nouvelle bis 2-difluoropyrrolo[2,1-c][1,4]benzodiazépine de formule (VII).

Affiliated with

Also associated with

Rating

Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2047521