Novel bisheterocyclic derivative or salt thereof

Details Novel bisheterocyclic derivative or salt thereof Novel bisheterocyclic derivative or salt thereof

C - Chemistry, Metallurgy

07

D

C07D 277/32 (2006.01) A61K 31/41 (2006.01) A61K 31/70 (2006.01) C07D 263/34 (2006.01) C07D 263/44 (2006.01) C07D 277/20 (2006.01) C07D 277/34 (2006.01) C07D 417/12 (2006.01) C07D 493/04 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2114001

ABSTRACT Image (I) Image (II) Image (III) A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R1 and R2 may be the same or different from each other and each represents (II) or (III), R3 represents hydrogen or a protective group, X, Y1 and Y2 may be the same or different from one another and each represents oxygen or sulfur, B1 and B2 represent each phenylene, B3 represents phenylene, naphthylene, cyclohexylene or furo[3,2- b]furanylene, L1 and L2 represent each -(O)n-A-, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L1 and L2 is bonded to B3. The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity.

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