Novel boronate esters

Details Novel boronate esters Novel boronate esters

C - Chemistry, Metallurgy

07

F

C07F 5/04 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2475586

The present invention relates to optically active dihydroxy hexanoate derivatives, boronate esters of formula IIa which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastatin, pitavastatin, fluvastatin. Image Ar = unsubstituted or substituted aryl or heteroaryl R3 = alkyl from 1 to 8 carbons, aryl or aralkyl R4 = O, OH, CN or a halogen and a =single bond or a double bond

L'invention concerne des dérivés optiquement actifs de dihydroxyhexanoate, des esters de boronate de formule (IIa) constituant des intermédiaires utiles pour la synthèse d'inhibiteurs de l'enzyme HMG-CoA, tels que l'atorvastatine, la cérivastatine, la rosuvastatine, la pitavastatine, et la fluvastatine. Dans cette formule, Ar représente un aryle ou un hétéroaryle non substitués ou substitués, R3 représente un alkyle présentant de 1 à 8 carbones, ou un aryle ou un arylalkyle, et R4 représente O, OH, CN ou un halogène et </= a >/= représente une liaison simple ou une double liaison.

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