Novel boronic acid-containing nucleic acids and their use as...

Details Novel boronic acid-containing nucleic acids and their use as... Novel boronic acid-containing nucleic acids and their use as...

C - Chemistry, Metallurgy

07

H

C07H 23/00 (2006.01) C07H 21/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2262618

Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.

Nucléotides et polynucléotides modifiés, s'utilisant dans des méthodes d'hybridation pour la détection de gènes cibles. Ces polynucléotides modifiés contiennent au moins une fraction d'acide borique rattachée à une base nucléotidique en une position qui ne perturbe pas les aptitudes de liaison à l'hydrogène de cette base au cours de la formation du duplex. Les polynucléotides modifiés décrits sont généralement composés de nucléotides naturels et d'un ou plusieurs nucléotides modifiés.

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