Novel borrelia burgdorferi polypeptides and uses thereof

Details Novel borrelia burgdorferi polypeptides and uses thereof Novel borrelia burgdorferi polypeptides and uses thereof

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/20 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2402727

The present invention provides novel polypeptides which are substantially free of a B. burgdorferi spirochete or fragments thereof and which are thus useful in compositions and methods for the treatment and prevention of B. burgdorferi infection and Lyme disease. In one preferred embodiment, this invention provides modified OspA polypeptides and pharmaceutically effective compositions and methods comprising those polypeptides. A preferred modified OspA polypeptide is set forth in Figure 1, below. Preferred modified OspA polypeptides are characterized by modifications which diminish and/or ablate their ability to bind the human MHC allele DRB*0401.

La présente invention concerne des nouveaux polypeptides qui sont sensiblement exempts de spirochète ou de fragments de spirochète B. burgdorferi et qui sont, par conséquent, utilisés dans des compositions et des méthodes destinées au traitement ou à la prévention d'infection à B. burgdorferi et de la maladie de Lyme. Dans un mode de réalisation préféré, cette invention concerne des polypeptides OspA modifiés et des compositions efficaces sur le plan pharmaceutique ainsi que des méthodes renfermant ces polypeptides. Un polypeptide OspA modifié préféré est présenté à la Figure 1, en bas. Les polypeptides OspA modifiés préférés sont caractérisés par des modifications diminuant et/ou éliminant leur aptitude à se lier à l'allèle humain MHC DRB*0401.

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