Novel branched substituted amino derivatives of...

Details Novel branched substituted amino derivatives of... Novel branched substituted amino derivatives of...

C - Chemistry, Metallurgy

07

D

C07D 249/14 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2398772

The invention relates to compounds of general formula (I), wherein in particular, R1, R2, and R3 represent, each independently of each other, hydrogen, a halogen atom; a (C1-C5)alkyl; a (C1-C5)alkoxy; a trifluoromethyl or a group S-R, wherein R represents a (C1-C5)alkyl; R4, R5 represents a (C1-C5)alkyl; an alkynyl with 3 to 5 carbon atoms; a (C3-C5)cycloalkyl or an Ra-X-(C1-C2)alkyl group wherein Ra represents a (C1-C3)alkyl and X represents O; R6 represents -CHR7R8 wherein R7 represents a phenyl group which can be substituted by one or more radicals Z' in position 3, 4 and 5, with Z' representing a halogen; a (C1-C5)alkyl; a (C1-C5)alkyl-X- or (C1-C3)alkyl-X-(C1-C2)alkyl or X represents O; or a methylenedioxy group; and R8 represents a (C1-C6)alkyl; a (C3-C5)cycloalkyl(C1-C3)alkyl; (C1-C3)alkyl-X-(C1-C3)alkyle wherein X represents O. These compounds are suitable for CRF receptors.

La présente invention concerne des composés de formule (I), dans laquelle notamment R1, R2, R3 représentent, chacun indépendamment l'un de l'autre, l'hydrogène, un atome d'halogène; un (C1- C5)alkyle; un (C1-C5)alcoxy; un trifluorométhyle ou un groupe S-R dans lequel R représente un (C1-C5)alkyle; R4, R5 représente un (C1- C5)alkyle; un alcynyle de 3 à 5 atomes de carbone; un (C3-C5)cycloalkyl ou un groupe R a -X-(C1-C2)alkyle dans lequel R a, représente un (C1-C3)alkyle et X représente O: R6 représente -CHR7R8 dans lequel R7 représente un groupe phényle pouvant être substitué en position 3, 4 et 5 par un ou plusieurs radicaux Z', avec Z' représentant un halogène; un (C1-C5)alkyle; un (C1-C5)alkyl-X- ou (C1- C3)alkyl-X-(C1-C2)alkyle où X représente O; ou un groupe méthylènedioxy; et R8 représente un (C1-C6)alkyle; un (C3- C5)cycloalkyl(C1-C3)alkyle; (C1-C3)alkyl-X-(C1-C3)alkyle où X représente O. Ces composés sont affins pour les récepteurs du CRF.

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