C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/056 (2006.01) A61K 31/4355 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2747565
The present application relates to novel C-1 substituted analogues of pancratistatin and 7-dexoypancratistatin of Formula (I), pharmaceutical compositions thereof and the use of said compounds of Formula (I) in the treatment of cancer The application also relates to processes for the preparation of said compound of Formula (I) and intermediates thereof.
La présente invention concerne de nouveaux analogues substitués en C-1 de la pancratistatine et de la 7-désoxypancratistatine de formule (I), des compositions pharmaceutiques les renfermant et l'utilisation desdits composés de formule (I) dans le traitement du cancer. L'invention a également pour objet des méthodes de préparation desdits composés de formule (I) et de leurs intermédiaires.
Collins Jonathan
Hudlicky Tomas
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Brock University
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