Novel c-2 s/o- and s/n formaldehyde acetal derivatives of...

Details Novel c-2 s/o- and s/n formaldehyde acetal derivatives of... Novel c-2 s/o- and s/n formaldehyde acetal derivatives of...

C - Chemistry, Metallurgy

07

D

C07D 477/20 (2006.01) A61K 31/407 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2338776

The compounds of general formula (I) wherein R1 denotes hydrogen, hydroxymethyl or 1-hydroxyethyl, R2 denotes hydrogen or methyl and R3 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are broad spectrum antibiotics and .beta.-lactamase inhibitors.

L'invention porte sur des composés de formule (I) dans laquelle: R<1> est H, hydroxyméthyle ou 1-hydroxyméthyle, R<2> est H ou méthyle, et R<3> est un groupe pharmacocompatible lié à la partie restante de la molécule par une liaison unique oxygène-carbone, ou par une liaison unique azote-carbone, et sur leurs sels, esters et amides dérivés pharmacocompatibles qui s'avèrent être des antibiotiques à large spectre et des inhibiteurs de la beta -lactamase.

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