C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 63/00 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61K 45/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07J 53/00 (2006.01)
Patent
CA 2711420
The invention relates to 21 -keto triterpene compounds of formula (I): wherein R 1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HN activity. Thus, the in-vention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
La présente invention concerne des composés de 21-céto triterpènes de formule (I) : R1, X et Y étant tels que définis dans le descriptif, ainsi que des sels et des solvates de ceux-ci pharmaceutiquement acceptables. Ces composés présentent une activité anti-VIH importante. Ainsi, l'invention concerne également des procédés de prévention ou de traitement des infections par le VIH par administration de quantités thérapeutiquement efficaces d'un composé de formule (I), ou d'un sel ou solvate de celui-ci pharmaceutiquement acceptable, au patient nécessitant un tel traitement.
Chan Chun Kong Laval
Chauret Nathalie
Courchesne Marc
Halab Liliane
Moinet Christophe
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Virochem Pharma Inc.
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