Novel c18 modified retrosteroids as progesterone receptor...

C - Chemistry – Metallurgy – 07 – J

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C07J 15/00 (2006.01) A61K 31/57 (2006.01) A61P 5/34 (2006.01) A61P 5/36 (2006.01)

Patent

CA 2624015

Described herein are new retrosteroidal compounds of general formula (I), representing progesterone receptor modulators, and their production, and pharmaceutical preparations containing these compounds. Said compounds are preferably used for the treatment of benign gynecological disorders such as endometriosis and uterine fibroids, as well as for female birth control and for HRT.

L'invention concerne des composés rétrostéroïdaux de formule générale (I), représentant des modulateurs des récepteurs de la progestérone, la production de ceux-ci et des préparations pharmaceutiques renfermant ces composés. Ceux-ci sont utilisés, de préférence, pour le traitement de troubles gynécologiques bénins, tels que l'endométriose et des fibromyomes utérins, ainsi que pour la contraception féminine et HRT.

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