Novel camptothecin derivatives

Details Novel camptothecin derivatives Novel camptothecin derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2309196

The present invention relates to new camptothecin derivatives shown by the below formula, which are water-soluble and excellent in an anti-tumor activity, and to salts thereof. (see formula I) In the formula, R1 represents a hydrogen atom or an alkyl group with 1-6 carbon atoms, R2 represents identically or differently 0-4 alkyl groups with 1-6 carbon atoms, a halogen atom, an alkoxyl or hydroxyl group, R3represents a lower alkylamino, di-lower alkylamino, arylamino, cyclicamino or lower alkoxyl group, and salts thereof.

L'invention concerne de nouveaux dérivés de la camptothécine de la formule générale (1) et des sels desdits dérivés, solubles dans l'eau et ayant un excellent effet anticancéreux. Dans ladite formule, R<1> est hydrogène ou alkyle C1-C6; zéro à quatre groupes R<2> peuvent être identiques ou différents et représenter chacun alkyle C1-C6, halogéno, alcoxy ou hydroxy; et R<3> est alkylamino inférieur, di(alkyle inférieur)amino, arylamino, amino cyclique ou alcoxy inférieur.

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