C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/44 (2006.01) C07D 209/00 (2006.01) C07D 213/64 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2315897
The invention concerns novel camptothecin tetracyclic analogues of formula (I), preparation methods, applications as medicines and pharmaceutical compositions containing them. Said analogues, among which figures in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity for inhibiting topoisomerase I and/or topoisomerase II.
L'invention concerne de nouveaux analogues tétracycliques de la camptothécine de formule (1), leurs procédés de préparation, leur application comme médicaments et les compositions pharmaceutiques les contenant. Lesdits analogues, au nombre desquels figure notamment l'acide 3-hydroxy-3-(4-oxo-4,6 dihydroindolizino [1,2-b] quinoléin-2- yl) pentanoïque, présentent une activité biologique puissante d'inhibition de la topoisomérase I et/ou de la topoisomérase II.
Bigg Dennis
Lanco Christophe
Lavergne Olivier
Rolland Alain
Ulibarri Gerard
Goudreau Gage Dubuc
Ipsen Pharma S.a.s
Societe de Conseils de Recherches Et D'applications Scientifique
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