C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/00 (2006.01) C07C 271/08 (2006.01) C07C 271/12 (2006.01) C07C 271/16 (2006.01) C07C 323/19 (2006.01) C07D 213/30 (2006.01) C07D 213/61 (2006.01) C07D 213/69 (2006.01) C07D 213/70 (2006.01)
Patent
CA 2176968
(R)-2-ary1-1,3-propanediol monocarbamate and its intermediate, (R)-3-axtoxy-2-arylpropanol carbamate, represented by formulae (I) and (II), respectively, have pharmaceutically useful activity against central nervous system disorders including nervous myalgia, epilepsy and cerebral apoplexy, wherein, R is (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), wherein X is an oxygen atom or a sulfur atom; and Y represents a halogen element, trifluoromethyl, or a lower alkyl group containing one to three carbon atoms.
Monocarbamate de (R)-2-aryl-1,3-propanediol et son intermédiaire, le carbamate de (R)-3-acétoxy-2-arylpropanol, répondant respectivement aux formules (I) et (II), et présentant une activité pharmaceutiquement utile dirigée contre les troubles du système nerveux central tels que la myalgie nerveuse, l'épilepsie et l'apoplexie cérébrale. Dans lesdites formules, R représente (a), (b), (c), (d), (e), (f), (g), (h), (i), ou (j), où X représente un atome d'oxygène ou de soufre; et Y représente un élément halogène, trifluorométhyle ou un groupe alkyle inférieur renfermant de un à trois atomes de carbone.
Choi Yong-Moon
Han Dong-Il
Kim Hyung-Cheol
Lee Kwang-Hyouk
Goudreau Gage Dubuc
Yukong Limited
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