Novel carbamates and ureas as modifiers of multi-drug...

Details Novel carbamates and ureas as modifiers of multi-drug... Novel carbamates and ureas as modifiers of multi-drug...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/395 (2006.01) C07C 219/04 (2006.01) C07D 211/60 (2006.01) C07D 213/30 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2186380

The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylatic agents. This comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.

La présente invention concerne des composés représentés par la formule générale (I). Ces composés sont susceptibles de conserver, accroître ou rétablir la sensibilité des cellules à des agents thérapeutiques ou prophylactiques, lesquels agents contiennent ces composés comme principes actifs. Les composés et les compositions pharmaceutiques de la présente invention sont particulièrement adaptés au traitement contre les cellules résistant à la multi-médicamentation, à la prévention de l'extension de la résistance à la multi-médicamentation, et à l'utilisation thérapeutique contre les cancers résistant à la multi-médicamentation.

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