Novel carbapenem derivatives

Details Novel carbapenem derivatives Novel carbapenem derivatives

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/425 (2006.01) C07D 477/14 (2006.01)

Patent

CA 2338816

Novel compounds having a broad antibacterial activity over gram-positive and gram-negative bacteria, in particular, a potent antibacterial effect on .beta.- lactamase producing bacteria, MRSA, tolerant Pseudomonas aeruginosa, DRSP, Enterococcus and Haemophilus influenzae and an extremely high stability to DHP- 1. These compounds are those represented by general formula (I), pharmaceutically acceptable salts thereof and esters of the carboxylic acid at the 3-position of the carbapenem ring thereof.

La présente invention porte sur de nouveaux composés exerçant une grande activité antibactérienne, en particulier sur les bactéries gram-positives et gram-négatives, et un puissant effet antibactérien sur les bactéries productrices de .beta.-lactamase, sur le MRSA, sur les pseudomonas aeruginosa tolérantes, le DRSP, les enterococcus et l'Haemophilus influenza, et présentant une très grande stabilité au DHP-1. Par ailleurs, cette invention concerne ces composés représentés par la formule générale (I), leurs sels acceptables sur le plan pharmaceutique, et les esters de l'acide carboxylique en position 3 du cycle carbapenem.

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