Novel carbonyl reductase, gene encoding the same, and...

Details Novel carbonyl reductase, gene encoding the same, and... Novel carbonyl reductase, gene encoding the same, and...

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C12N 1/21 (2006.01) C12N 9/04 (2006.01) C12P 17/02 (2006.01) C12P 17/12 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2479705

It is intended to provide a novel carbonyl reductase originating in a microorganism belonging to the genus Ogataea and a DNA encoding this enzyme. By reducing ketones with the use of carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3- yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase is excellent in activity and stereoselectivity. Thus, a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc., is provided.

L'invention concerne une nouvelle carbonyl réductase existant dans un micro-organisme du genre Ogataea, et un ADN codant pour cette enzyme. En réduisant des cétones au moyen de carbonyl réductase, d'alcools optiquement actifs, on peut produire, en particulier, des esters d'acide (E)-7-[2-cyclopropyl-4-(4-fluorophényl)-quinoléine-3-yl]-3,5-dihydroxy-hept-6-énoïque. La carbonyl réductase présente une excellente activité et une excellente stéréosélectivité. L'invention concerne en conséquence un procédé de production d'alcools optiquement actifs, utilisés industriellement comme produits intermédiaires pour des médicaments, des pesticides, etc.

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