C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) C12N 1/21 (2006.01) C12N 9/04 (2006.01) C12N 15/53 (2006.01) C12P 7/62 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2360376
A novel polypeptide for producing tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate, a gene encoding the polypeptide, and a method of using the polypeptide, are provided. The polypeptide has an enzyme activity to asymmetrically reduce tert-butyl (S)-6-chloro-5- hydroxy-3-oxohexanoate to tert-butyl (3R,5S)-6-chloro- 3,5-dihydroxyhexanoate. The polypeptide comprises the amino acid sequence represented by SEQ ID NO. 1 in the Sequence Listing, or the amino acid sequence having at least one amino acid substitution, insertion, deletion, or addition thereof.
L'invention concerne un nouveau polypeptide capable de former un tert-butyl (3R, 5S)-6-chloro-3,5-dihydroxyhexanoate ; ainsi qu'un polynucléotide codant ledit polypeptide. L'invention concerne, en l'occurrence, un polypeptide qui, de par son activité enzymatique, réduit asymétriquement le tert-butyl(S)-6-chloro-5-hydroxy-3-oxohexanoate en tert-butyl(3R, 5S)-6-chloro-3,5-dihydroxyhexanoate, et contient la séquence d'acides aminés représentée par SEQ ID NO:1 dans la liste des séquences ou une séquence d'acides aminés dérivée de la séquence d'acides aminés précitée par substitution, insertion, délétion ou addition d'un acide aminé au moins.
Hasegawa Junzo
Kizaki Noriyuki
Yamada Yukio
Yasohara Yoshihiko
Deeth Williams Wall Llp
Kaneka Corporation
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