Novel carboxy substituted cyclic carboxamide derivatives

Details Novel carboxy substituted cyclic carboxamide derivatives Novel carboxy substituted cyclic carboxamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2275602

The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

La présente invention a trait à de nouveaux dérivés carboxamides cycliques substitués par carboxy et représentés par la formule (1), à des stéréo-isomères et à des sels pharmaceutiquement acceptables de ces dérivés, et à leur utilisation comme antagonistes des récepteurs de tachykinine. De tels antagonistes sont efficaces dans le traitement des maladies induites par la tachykinine ainsi que les troubles tels que l'asthme, la toux et la bronchite.

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