Novel carboxylesterase nucleic acid molecules, proteins and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) C07K 14/435 (2006.01) C12N 9/18 (2006.01) C12N 15/52 (2006.01) C12N 15/55 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2271951

The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.

L'invention se rapporte à des protéines d'estérase d'arthropodes; à des molécules d'acide nucléique d'estérase d'arthropodes, dont celles qui codent lesdites protéines d'estérase; à des anticorps qui s'attaquent auxdites protéines; et à d'autres composés qui inhibent l'activité de l'estérase d'arthropodes. L'invention comprend également des procédés d'obtention desdites protéines, desdites molécules d'acide nucléique, desdits anticorps et desdits composés inhibiteurs. L'invention se rapporte en outre à des compositions thérapeutiques contenant lesdites protéines, lesdites molécules d'acide nucléique, lesdits anticorps et/ou lesdits composés inhibiteurs et également à l'utilisation desdites compositions thérapeutiques afin de protéger des animaux d'infestation par des arthropodes hématophages.

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