Novel carotenoids ketolases

C - Chemistry – Metallurgy – 12 – P

Patent

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Details

C12P 23/00 (2006.01) C07H 21/04 (2006.01) C12N 1/20 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2550376

Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW ketolases previously reported. Expression of the carotenoid ketolases in heterologous hosts enabled production of canthaxanthin and astaxanthin. Coexpression experiments using divergent crtW genes resulted in increased production of the desired ketocarotenoids

La présente invention concerne de nouvelles cétolases de caroténoïde qui sont utiles pour produire des cétocaroténoïdes. Les gènes de cétolases selon la présente invention présentent une faible homologie comparativement à d'autres cétolases CrtW déjà présentées. L'expression des cétolases de caroténoïde dans des hôtes hétérologues a permis de produire de la canthaxanthine et de l'astaxanthine. Des expériences de coexpression effectuée à l'aide de gènes crtW divergents ont donné lieu à une production accrue des cétocaroténoïdes désirés.

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