C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2261023
The present invention discloses nucleic acid enzymes capable of cleaving nucleic acid molecules, including single-stranded DNA, in a site-specific manner under physiologic conditions, as well as compositions including same. The present invention also discloses methods of making and using the disclosed enzymes and compositions. The present invention further discloses nucleic acid enzymes or catalytic (enzymatic) RNA molecules that are capable of cleaving a variety of bonds, including phosphodiester bonds and amide bonds, in a variety of substrates. Thus, various disclosed enzymatic RNA molecules are capable of functioning as nucleases, amidases, and/or peptidases. The present invention also relates to compositions containing the disclosed catalytic RNA molecules and to methods of making, selecting, and using such enzymes and compositions.
La présente invention concerne des enzymes d'acide nucléique capables, dans certaines conditions physiologiques, de scinder, de façon dirigée, des molécules d'acide nucléique, y compris d'ADN monocaténaire, ainsi que des compositions comprenant ces derniers. On décrit également des procédés de production et d'utilisation des enzymes et compositions faisant l'objet de l'invention. L'invention se rapporte en outre à des enzymes d'acide nucléique ou à des molécules d'ARN catalytique (enzymatique) capables de scinder une série de liaisons, y compris les liaisons phosphodiester et les liaisons amides, sur des substrats variés. Plusieurs molécules d'ARN enzymatique ci-décrites sont par conséquent capables d'agir comme nucléases, amidases et/ou peptidases. La présente invention concerne également des compositions contenant les molécules d'ARN catalytique ci-décrites et des procédés de production, de sélection et d'utilisation desdits enzymes et compositions.
Fetherstonhaugh & Co.
The Scripps Research Institute
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