C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 38/05 (2006.01) C07H 21/00 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2221684
Methods for inhibiting the secretion of .beta.-amyloid peptide (.beta.AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in .beta.AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for .beta.AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.
Cette invention concerne des procédés d'inhibition de la sécrétion de peptide beta -amyloïde ( beta AP) par des cellules, lesquels procédés consistent à administrer aux cellules certains composés qui inhibent l'activité d'une protéase d'approximativement 31 kD impliquée dans la sécrétion de beta AP. Cette protéase de 31 kD a été désignée sous le nom de Cathepsine Y. Cette invention concerne également des procédés de criblage d'inhibiteurs de beta AP, qui consistent à déterminer l'activité de composés tests en présence de la Cathepsine Y et d'un substrat peptidique adéquat. Cette invention concerne enfin une séquence d'acide nucléique codant la Cathepsine Y, ainsi que l'expression et l'isolation de la Cathepsine Y.
Anderson John
Chrysler Susanna
Mcconlogue Lisa
Semko Christopher M. F.
Sinha Sukanto
Athena Neurosciences Inc.
Torys Llp
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