Novel cationic phospholipids for transfection

Details Novel cationic phospholipids for transfection Novel cationic phospholipids for transfection

C - Chemistry, Metallurgy

07

F

C07F 9/10 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) C07F 9/113 (2006.01) C07F 9/547 (2006.01) C07F 9/653 (2006.01) C07H 21/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2186588

A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because they are not only effective in lipofection, but are extremely cheap and easy to make.

Nouvelle classe de phospholipides cationiques et nouveau procédé de synthèse de ces derniers. Cette classe de phospholipides comprend des dérivés phosphotriester de phosphoglycérides et de sphingolipides. Il a été découvert que, contre toute attente, des liposomes comprenant au moins un de ces phospholipides cationiques permettent d'assurer efficacement la transfection par liposomes d'acides nucléiques. Ces nouveaux phospholipides sont particulièrement avantageux, non seulement parce qu'ils assurent efficacement la transfection par liposomes, mais également parce qu'ils sont très peu coûteux et faciles à produire.

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