Novel cdnas encoding catenin-binding proteins with function...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2395143

The invention relates to the field of drug discovery, diagnosis, prognosis and treatment of cancer and neurological disorders. The invention provides among others access to and insight in protein-protein or protein-DNA interactions in a signal transduction or transcriptional pathway controlling cell growth or development throughout a wide range of cells and tissues of the body, and provides means, such as nucleic acid, protein, cells and experimental animals and methods to identify candidate drugs, for example for use in therapy of cancer or neurological disorders. As an example of an alpha-catenin-binding protein with function in intracellular signalling or gene regulation, the invention provides an isolated and/or recombinant nucleic acid or a functional fragment, homologue or derivative thereof, corresponding to a zinc finger gene with a nucleic acid sequence (as shown in figure 1) and encoding a zinc finger protein, or fragment thereof, capable of complexing with a neurally expressed catenin.

L'invention concerne le domaine de la recherche de médicaments, du diagnostic, du pronostic et du traitement du cancer et de maladies neurologiques. Elle concerne les interactions entre des protéines ou entre des protéines et l'ADN dans un trajet de transduction de signal ou de transcription contrôlant la croissance cellulaire ou son développement dans une gamme étendue de cellules et de tissus corporels, et concerne des moyens, tels que les acides nucléiques, les protéines, les cellules et les animaux d'expérimentation, ainsi que des procédés servant à identifier des médicaments candidats, afin, par exemple, de les utiliser en thérapie du cancer ou de maladies neurologiques. En tant qu'exemple d'une protéine de fixation à alpha-caténine exerçant une fonction de signalisation intracellulaire ou de régulation génique, l'invention concerne un acide nucléique isolé et/ou recombinant, ou un de ces fragments fonctionnels, homologues ou dérivés, correspondant à un gène digital de zinc possédant la séquence d'acides nucléiques illustrée par la figure 1 et codant une protéine de zinc digital, ou un de ces fragments, capable de constituer un complexe avec une caténine d'expression neurale.

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