Novel cell cycle checkpoint genes and proteins encoded thereby

Details Novel cell cycle checkpoint genes and proteins encoded thereby Novel cell cycle checkpoint genes and proteins encoded thereby

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) C12N 1/36 (2006.01)

Patent

CA 2385266

The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repairgenes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

L'invention concerne des nouveaux gènes de point de contrôle à cycle cellulaire mammifères, des gènes de réparation de l'ADN, un ADN complémentaire ou un ADN génomique, des acides nucléiques isolés correspondant, des vecteurs d'expression comprenant lesdits acides nucléiques, des cellules hôtes transformées par les vecteurs d'expression susmentionnés, des compositions pharmaceutiques ainsi que la préparation de telles compositions comprenant ces acides nucléiques ou les protéines exprimées. L'invention concerne également des procédés permettant de traiter une cellule grâce à ces acides nucléiques, à ces protéines ou à ces compositions pharmaceutiques. En outre, l'invention concerne l'utilisation de ces acides nucléiques ou de ces protéines dans la préparation d'une composition pharmaceutique.

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