Novel cells and molecules involved in immune regulation

Details Novel cells and molecules involved in immune regulation Novel cells and molecules involved in immune regulation

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/13 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2316089

Novel cells and molecules involved in immune regulation are disclosed. The novel cells are regulatory T cells having the phenotype CD3+.alpha..beta.-TcR+CD4-CD8-CD44-CD28-NK1.1-. The regulatory cells express high levels of Ly-6A and osteopontin while non-regulatory cells do not. Inhibiting Ly-6A or osteopontin inhibits the suppressive properties of the cells.

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