G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01)
Patent
CA 2692445
The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.
L'invention concerne de nouvelles compositions de glycanes, de glycomes, provenant de cellules souches embryonnaires humaines, et, en particulier, de nouvelles sous-compositions des glycomes avec des compositions monosaccharidiques et des structures de glycanes spécifiques. L'invention concerne en outre des procédés pour modifier les glycomes et analyser les glycomes, ainsi que les glycomes modifiés. De plus, l'invention concerne des cellules souches portant les glycomes modifiés sur leurs surfaces. Les glycomes sont, de préférence, analysés par des méthodes d'établissement de profils, capables de détecter de façon reproductible et quantitative de nombreuses structures de glycanes individuelles en même temps. Le type de profil que l'on préfère le plus est un profil de spectromètre de masse. L'invention concerne spécifiquement de nouvelles structures cibles et se rapporte en particulier au développement de réactifs reconnaissant les structures.
Heiskanen Annamari
Jaatinen Taina
Laine Jarmo
Mikkola Milla
Natunen Jari
Borden Ladner Gervais Llp
Glykos Finland Oy
Suomen Punainen Risti Veripalvelu
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