C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/20 (2006.01) A61K 31/55 (2006.01) C07C 57/13 (2006.01) C07C 59/42 (2006.01) C07C 59/48 (2006.01) C07C 69/732 (2006.01) C07D 209/00 (2006.01) C07D 223/00 (2006.01) C07D 303/48 (2006.01) C07D 305/08 (2006.01) C07D 307/00 (2006.01) C07D 309/08 (2006.01) C07D 317/00 (2006.01) C07D 331/00 (2006.01) C07D 453/04 (2006.01) C07D 493/10 (2006.01)
Patent
CA 2324895
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
L'invention concerne une nouvelle méthode permettant d'effectuer une semi-synthèse asymétrique d'haringtonines et de leurs analogues, qui sont des alcaloïdes utilisés en chimiothérapie. Cette méthode comprend l'estérification directe d'une céphalotaxine avec un composé d'acylation constitué d'un précurseur de chaîne latérale dont le squelette et les groupes fonctionnels sont entièrement préformés.
Cavoleau Sylvie
Charbonnel Sandra
Chauviat Ludovic
Dhal Robert
Dujardin Gilles
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Oncopharm Corporation
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