Novel chalcone derivatives and uses thereof

Details Novel chalcone derivatives and uses thereof Novel chalcone derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 215/26 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/403 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/47 (2006.01) C07C 49/84 (2006.01) C07D 217/24 (2006.01) C07D 263/56 (2006.01) C07D 277/62 (2006.01) C07D 307/86 (2006.01) C07D 333/54 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2478921

Various chalcone derivatives of the general formula (I) are described and the variables, A, B, m and R1 to R10 are as defined in the specification. These derivatives can be useful in the modulation of potassium channel activity in cells and may be useful in the treatment or prevention of autoimmune and inflammatory diseases.

Cette invention décrit divers dérivés de chalcone représentés par la formule générale (I), les variables A, B, m et R?1¿ à R?10¿ étant telles que définies dans la description. Ces dérivés peuvent être utilisés pour moduler l'activité du canal potassique dans des cellules et peuvent servir au traitement ou à la prévention de maladies auto-immunes et inflammatoires.

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